Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast
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چکیده
منابع مشابه
Improved bioavailability through floating microspheres of lovastatin
BACKGROUND AND THE PURPOSE OF THE STUDY Lovastatin is an antihyperlipidemic agent which has low bioavailability due to the extensive first pass metabolism. It was sought to increase gastric retention of lovastatin by development of a sustained release gastroretentive drug delivery system leading to reduced fluctuation in the plasma concentration and improved bioavailability. MEHODS: Floating m...
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In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a t...
متن کاملMicrobial Production and Biomedical Applications of Lovastatin
Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. Lovastatin acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabol...
متن کاملA review on lovastatin and its production
Natural statin like lovastatin which is mainly produced by Aspergillus terreus strains is an inhibitor of HMG-CoA reductase, an enzyme involved in the biosynthetic pathway of cholesterol. The mechanism involved in controlling plasma cholesterol levels is the reversible competitive inhibition of HMG-CoA which binds to the HMG-CoA reductase due to the structural homology between the β-hydroxyacid...
متن کاملA Review: Lovastatin Production and Applications
Cholesterol is an organic compound, which is produced in humans by a complex metabolism. It acts as a precursor for the synthesis of many steroids, vitamin D and also helps in membrane transport. Increase of cholesterol in humans, leads to Cardio Vascular Disorders and finally death. This can be reduced by inhibiting the HMG-CoA reductase, which is an important precursor in formation of mevolan...
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ژورنال
عنوان ژورنال: Bioresources and Bioprocessing
سال: 2018
ISSN: 2197-4365
DOI: 10.1186/s40643-018-0202-z